Melancholy Depressive Disorder
When something feels off
When your stomach mildly churns away day after day
Into the night and then again before the sun rises
When no amount of morning dew brings freshness
When peace becomes a greater need than bread or water
There appears to be a strong
trend of decreased 5-HT1A receptor expression in MDD. Biochemically, the polymorphism of the C-1019G promoter (rs6295), a genetic variant of the 5-HT1A receptor, has shown to have the G allele is more frequently in MDD.
Clears it up nicely...
The difference between depression and melancholia
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